Tyrosine hydroxylase: delayed activation in central noradrenergic neurons and induction in adrenal medulla elicited by stimulation of central cholinergic receptors.

@article{Lewander1977TyrosineHD,
  title={Tyrosine hydroxylase: delayed activation in central noradrenergic neurons and induction in adrenal medulla elicited by stimulation of central cholinergic receptors.},
  author={Tommy Lewander and Tong H. Joh and Donald J. Reis},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1977},
  volume={200 3},
  pages={523-34}
}
The centrally active muscarinic agonist, oxotremorine, elicited an up to 2-fold dose-dependent (0.25-1.5 mg/kg) increase in the activity of tyrosine hydroxylase (TH) in the rat nucleus locus coeruleus (LC) and adrenal medulla. The response occurred in LC after 24 to 48 hours and in adrenal medulla by 4 to 8 hours, peaked in LC at 72 hours and adrenal… CONTINUE READING