Tyrosine aminotransferase: The entrypoint enzyme of the tyrosine-derived pathway in rosmarinic acid biosynthesis

@article{DeEknamkul1987TyrosineAT,
  title={Tyrosine aminotransferase: The entrypoint enzyme of the tyrosine-derived pathway in rosmarinic acid biosynthesis},
  author={Wanchai De-Eknamkul and Brian E. Ellis},
  journal={Phytochemistry},
  year={1987},
  volume={26},
  pages={1941-1946}
}
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64 Citations
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14
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64 Citations

Behavior of Free Aromatic Amino Acid Pools in Rosmarinic Acid-Producing Cell Cultures of Anchusa officinalis L.

It is suggested that there exists a close coupling between the l-tyrosine pool and the rosmarinic acid biosynthetic pathway, which may involve the channelling of intermediates both into and within the pathway.

Rosmarinic acid formation and differential expression of tyrosine aminotransferase isoforms in Anchusa officinalis cell suspension cultures

Both T AT-1 and TAT-4 are closely involved in RA biosynthesis, as well as the substrate specificity of each TAT isoform.

Tyrosine Aminotransferase Contributes to Benzylisoquinoline Alkaloid Biosynthesis in Opium Poppy1[W]

The modest correlation between transcript levels and BIA accumulation in opium poppy supports a role for TyrAT in the generation of alkaloid precursors, but it also suggests the occurrence of other sources for 4-hydroxyphenylacetaldehyde.

Identification and biochemical characterisation of tyrosine aminotransferase from Anthoceros agrestis unveils the conceivable entry point into rosmarinic acid biosynthesis in hornworts

This work presents the first description of a heterologously expressed TAT from a hornwort and describes the possible entry into the biosynthesis of RA and other specialised compounds in a so far neglected representative of terrestrial plants and upcoming new model organism.

Phenylalanine ammonia-lyase (PAL) gene activity in response to proline and tyrosine in rosemary callus culture

Investigation of the PAL gene activity in the callus of rosemary due to exogenous application of L-proline and L-tyrosine found that it was found that RA production increased significantly at low proline application, while tyrosine application at low concentrations had no effect on RA accumulation, while high tyrosin concentration increased RA accumulation.

The biosynthesis of rosmarinic acid in suspension cultures of Coleus blumei

All the enzymes necessary for the formation of rosmarinic acid from the precursors phenylalanine and tyrosine could be isolated from cell cultures of Coleus blumei, and the main characteristics of these enzymes of the proposed biosynthetic pathway of roedic acid will be described.

Biosynthesis and Accumulation of Rosmarinic Acid in Plant Cell Cultures

The regulation of RA biosynthesis and accumulation on the enzyme as well as the gene level is studied in the model system Coleus blumei, which contributes to the pharmacological and food-preserving qualities of these plants.

Molecular Cloning and Characterization of Tyrosine Aminotransferase and Hydroxyphenylpyruvate Reductase, and Rosmarinic Acid Accumulation in Scutellaria baicalensis

The transcript levels of TAT isoforms and HPPR were higher than those in other organs and RA was also highly accumulated in the flowers and with a trace amount in the roots, helping in elucidating the mechanisms of RA biosynthesis in S. baicalensis.

Kinetic analysis of the inhibition of phenylalanine ammonia-lyase by 2-aminoindan-2-phosphonic acid and other phenylalanine analogues.

Characterization of rosmarinic acid synthase from cell cultures of coleus blumei

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References

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