Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions.

@article{Melamed1980TyrosineAI,
  title={Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions.},
  author={Eldad Melamed and Franz Hefti and Richard J. Wurtman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1980},
  volume={77 7},
  pages={
          4305-9
        }
}
Partial, unilateral nigrostriatal lesions of varying severity were produced in rats by injecting graded doses of 6-hydroxydopamine into the substantia nigra. Formation of the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid in each surviving nigrostriatal neuron (estimated by the ratios of dihydroxyphenylacetic acid to dopamine and homovanillic acid to dopamine in the striatum) increased significantly when dopamine concentrations in striata containing lesions had been… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

Non-nutritional uses of nutrients.

  • European journal of pharmacology
  • 2011
VIEW 2 EXCERPTS
CITES BACKGROUND