Tyrosine accelerates catecholamine synthesis in hemorrhaged hypotensive rats

@article{Conlay1985TyrosineAC,
  title={Tyrosine accelerates catecholamine synthesis in hemorrhaged hypotensive rats},
  author={Lydia A. Conlay and Timothy J. Maher and Richard J. Wurtman},
  journal={Brain Research},
  year={1985},
  volume={333},
  pages={81-84}
}
Tyrosine, the amino acid precursor of catecholamines, increases blood pressure (BP) in rats made hypotensive by hemorrhage. Since this amino acid also accelerates catecholamine synthesis in and release from frequently-firing neurons, we tested the hypothesis that tyrosine's pressor action resulted from this mechanism. Male Sprague-Dawley rats (500 g) were anesthetized with chloralose (50 mg/kg) and urethane (500 mg/kg) and tracheostomized. The carotid artery was cannulated allowing BP to be… CONTINUE READING

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