Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains

  title={Tyrosine Phosphorylation of Botulinum Neurotoxin Protease Domains},
  author={Stephen I Toth and Ernst E. Brueggmann and George A. Oyler and L. A. Smith and Harry B. Hines and S. Ashraf Ahmed},
  booktitle={Front. Pharmacol.},
Botulinum neurotoxins are most potent of all toxins. Their N-terminal light chain domain (Lc) translocates into peripheral cholinergic neurons to exert its endoproteolytic action leading to muscle paralysis. Therapeutic development against these toxins is a major challenge due to their in vitro and in vivo structural differences. Although three-dimensional… CONTINUE READING