Tyrosine Augments Acute Clozapine- but not Haloperidol-Induced Dopamine Release in the Medial Prefrontal Cortex of the Rat: An in vivo Microdialysis Study

@article{Jaskiw2001TyrosineAA,
  title={Tyrosine Augments Acute Clozapine- but not Haloperidol-Induced Dopamine Release in the Medial Prefrontal Cortex of the Rat: An in vivo Microdialysis Study},
  author={George E. Jaskiw and Keith A. Collins and Elizabeth A. Pehek and Bryan K. Yamamoto},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={25},
  pages={149-156}
}
Tyrosine availability can influence dopamine (DA) synthesis in highly electrophysiologically active DAergic neurons, such as those innervating the medial prefrontal cortex (MPFC). Whether tyrosine concentrations can also affect MPFC extracellular DA concentrations, measured in vivo, is not known. Since clozapine preferentially activates mesocortical DA neurons, we posited that tyrosine administration to a clozapine-pretreated rat would enhance the clozapine-induced augmentation of MPFC… CONTINUE READING

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