Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future

@article{Kim2005TyrosinaseIF,
  title={Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future},
  author={Y.-J. Kim and H. Uyama},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2005},
  volume={62},
  pages={1707-1723}
}
  • Y. Kim, H. Uyama
  • Published 15 May 2005
  • Chemistry, Medicine
  • Cellular and Molecular Life Sciences CMLS
Abstract.Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional… Expand
Natural and Synthetic Tyrosinase Inhibitors as Antibrowning Agents: An Update
Abstract:  Tyrosinase (EC 1.14.18.1), a copper-containing enzyme, can cause enzymatic browning in raw fruits, vegetables, and beverages. Browning is an undesirable reaction that is responsible forExpand
Naturally occurring and synthetic peptides: Efficient tyrosinase inhibitors
TLDR
Among a wide range of compounds possessing anti‐tyrosinase activity, peptides both natural and synthetic derivatives have attracted attention due to high potency and safety. Expand
Natural, semisynthetic and synthetic tyrosinase inhibitors
TLDR
In this review, tyrosinase inhibitors with natural, semi-synthetic and synthetic origins are listed up with their structures, activities and characteristics. Expand
Stilbenes with tyrosinase inhibitory activity
Tyrosinase (EC 1.14.18.1) is a multicopper monooxygenase enzyme with wide distribution. In mammals, it is responsible for pigmentation of skin, eyes and hair. The enzyme is involved in the undesiredExpand
An Updated Review of Tyrosinase Inhibitors
  • Te-Sheng Chang
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 2009
TLDR
This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources and the inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed. Expand
Searching for indole derivatives as potential mushroom tyrosinase inhibitors
TLDR
The idea was to screen the “in house” database to select suitable lead compounds for the discovery of potential drug-inhibiting enzyme, and it was demonstrated that compounds containing 4-fluorobenzyl moiety at N − 1 position of indole system showed the best activity. Expand
Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity
Tyrosinase is a key enzyme for melanin biosynthesis , catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effe ctive approach to control hyperpigmentation inExpand
Inhibitory Mechanism of Salidroside on Tyrosinase
Tyrosinase is a key rate-limiting enzyme in melanin synthesis which can be blocked to reduce melasma and freckles by inhibiting the activity of tyrosinase. Salidroside showed certain inhibitoryExpand
Flavonoid derivatives as potent tyrosinase inhibitors - a survey of recent findings between 2008-2013.
TLDR
It is underline that flavonoids should continue to be the focus of tyrosinase inhibition studies as the promising compounds. Expand
Microorganisms as a source of tyrosinase inhibitors: a review
TLDR
This article surveys tyrosinase inhibitors produced by microorganisms and hence, serves as an updated database of tyrosINase inhibitors from microbial sources. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 178 REFERENCES
A new type of tyrosinase inhibitors from natural products as potential treatments for hyperpigmentation.
Selected flavonoids were evaluated for their effects on melanin biosynthesis by using mushroom-tyrosinase assay. Out of 27 tested flavonoids, only six showed a potential inhibitory activity onExpand
A new type of tyrosinase inhibitors from natural products as potential treatments for hyperpigmentation.
TLDR
A new type of tyrosinase inhibitor from natural origin is revealed and these compounds will be further examined for their application for treatment of hyperpigmentation problems e.g. melasma and ephelides. Expand
Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots.
TLDR
This is the first study indicating that glabrene and isoliquiritigenin exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that isoflavenes and chalcones may serve as candidates for skin-lightening agents. Expand
Tyrosinase inhibitory flavonoids fromheterotheca inuloides and their structural functions
Abstract By bioassay-guided fractionations, quercetin was isolated as the principal tyrosinase inhibitor from the dried flowers of Heterotheca inuloides Cass (Compositae). This flavonol inhibited theExpand
Inhibition of tyrosinase by flavonoids, stilbenes and related 4-substituted resorcinols: structure-activity investigations.
TLDR
Kinetic studies have indicated that specific compounds having the 4-substituted resorcinol skeleton exhibit competitive inhibition of the oxidation of DL-beta-(3,4-dihydroxyphenyl)alanine (DL-DOPA) by mushroom tyrosinase, which could lead to the design and discovery of new tyosinase inhibitors. Expand
Tyrosinase inhibitory activity of the olive oil flavor compounds.
TLDR
A series of alpha,beta-unsaturated aldehydes characterized from the olive Olea europaea L. (Oleaceae) oil flavor was found to inhibit the oxidation of L-3, 4-dihydroxyphenylalanine catalyzed by mushroom tyrosinase, and the inhibition kinetics analyzed by a Lineweaver-Burk plot found that they are noncompetitive inhibitors. Expand
Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism.
A common flavonol, kaempferol, isolated from the fresh flower petals of Crocus sativus L. (Iridaceae) was found to inhibit the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) catalyzed by mushroomExpand
Purification and properties of tyrosinase inhibitor from mushroom
TLDR
The properties of a tyrosinase inhibitor purified by column and affinity chromatography are described, indicating different entities even from the same sources. Expand
Inhibition of tyrosinase by green tea components.
TLDR
A competitive nature of GCG with this enzyme for the L-tyrosine binding at the active site of tyrosinase is revealed, which indicates that the consumption of green tea may help prevent cancers in humans and also reduce several free radicals including peroxynitrite. Expand
Molecular design of antibrowning agents: antioxidative tyrosinase inhibitors
Abstract Dodecyl (C12) gallate (3,4,5-trihydroxybenzoate) was found to inhibit the oxidation of l -3,4-dihydroxyphenylalanine ( l -DOPA) catalyzed by tyrosinase. This inhibition is a slow andExpand
...
1
2
3
4
5
...