Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice

@inproceedings{Sukseree2016TyrosinaseCreMediatedDO,
  title={Tyrosinase-Cre-Mediated Deletion of the Autophagy Gene Atg7 Leads to Accumulation of the RPE65 Variant M450 in the Retinal Pigment Epithelium of C57BL/6 Mice},
  author={Supawadee Sukseree and Ying-Ting Chen and Maria Laggner and Florian Gruber and Val{\'e}rie Petit and I Nagelreiter and Veronika Mlitz and Heidemarie Rossiter and Andreas Pollreisz and Ursula M Schmidt-Erfurth and Lionel Larue and Erwin Tschachler and Leopold Eckhart},
  booktitle={PloS one},
  year={2016}
}
Targeted gene knockout mouse models have helped to identify roles of autophagy in many tissues. Here, we investigated the retinal pigment epithelium (RPE) of Atg7f/f Tyr-Cre mice (on a C57BL/6 background), in which Cre recombinase is expressed under the control of the tyrosinase promoter to delete the autophagy gene Atg7. In line with pigment cell-directed blockade of autophagy, the RPE and the melanocytes of the choroid showed strong accumulation of the autophagy adaptor and substrate… CONTINUE READING