Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor.

@article{SawkaVerhelle1997Tyr624AT,
  title={Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor.},
  author={Dominique Sawka-Verhelle and V{\'e}ronique T Baron and I Mothe and Chantal Filloux and Morris F. White and E Van Obberghen},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 26},
  pages={16414-20}
}
In addition to the pleckstrin homology domain and the phosphotyrosine binding domain in insulin receptor substrate (IRS)-1 and IRS-2, a region between amino acids 591 and 786 in IRS-2 (IRS-2-(591-786)) binds to the insulin receptor. Based on peptide competition studies, this region interacts with the phosphorylated regulatory loop of the insulin receptor; we designate this region the kinase regulatory loop binding (KRLB) domain. Two tyrosine residues in the KRLB domain at positions 624 and 628… CONTINUE READING