Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.

@article{Marie1994Tyr292IT,
  title={Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.},
  author={Jacky Marie and Bernard Maigret and Michael P. Joseph and R Larguier and S Nouet and Colette Lombard and Jean C Bonnafous},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 33},
  pages={20815-8}
}
An essential role of the conserved Asp74 in the coupling of the type 1 angiotensin II (AII) receptor (AT1) to phospholipase C has already been reported (Bihoreau, C., Monnot, C., Davies, E., Teutsch, B., Bernstein, K. B., Corvol, P., and Clauser, E. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5133-5137). Moreover, preliminary modeling studies have shown that a spatial proximity exists between Asp74, located in transmembrane domain II, and Tyr292, located in transmembrane domain VII and conserved… CONTINUE READING
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