Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.

@article{Arvidsson1994Tyr716IT,
  title={Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.},
  author={Annette Arvidsson and E E Rupp and E N{\aa}nberg and Julian Downward and Lars R{\"o}nnstrand and Stefan Wennstr{\"o}m and Joseph Schlessinger and C H Heldin and Lena Claesson-Welsh},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 10},
  pages={6715-26}
}
Ligand stimulation of the platelet-derived growth factor (PDGF) beta-receptor leads to activation of its intrinsic tyrosine kinase and autophosphorylation of the intracellular part of the receptor. The autophosphorylated tyrosine residues mediate interactions with downstream signal transduction molecules and thereby initiate different signalling pathways. A pathway leading to activation of the GTP-binding protein Ras involves the adaptor molecule GRB2. Here we show that Tyr-716, a novel… CONTINUE READING

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