• Biology, Medicine
  • Published in
    Progress in clinical and…
    1989

Typing of MHC haplotypes in OS chicken by means of RFLP analysis.

@article{Hla1989TypingOM,
  title={Typing of MHC haplotypes in OS chicken by means of RFLP analysis.},
  author={Karel H{\'a}la and Roswitha Sgonc and Charles Auffray and Georg Wick},
  journal={Progress in clinical and biological research},
  year={1989},
  volume={307},
  pages={
          177-86
        }
}
For the analysis of the genetic background of autoimmune thyroiditis we used the Obese strain (OS) chicken model which develops a SAT. Practically all animals from this strain show severe lymphoid infiltration of the thyroid gland and circulating autoantibodies against thyroglobulin (Tg-AAb) within a few weeks after hatching. Of the 3 MHC haplotypes (B5, B13, B15) present in the OS, B13 was mostly associated with severe thyroid infiltration. Haplotypes B5 and B15 were associated both with… CONTINUE READING