Typing African Relapsing Fever Spirochetes

  title={Typing African Relapsing Fever Spirochetes},
  author={Julie Christine Scott and David Julian Maurice Wright and Sally J Cutler},
  booktitle={Emerging infectious diseases},
Relapsing fever Borrelia spp. challenge microbiologic typing because they possess segmented genomes that maintain essential genes on large linear plasmids. Antigenic variation further complicates typing. Intergenic spacer (IGS, between 16S-23S genes) heterogeneity provides resolution among Lyme disease-associated and some relapsing fever spirochetes. We used an IGS fragment for typing East African relapsing fever Borrelia spp. Borrelia recurrentis and their louse vectors showed 2 sequence types… CONTINUE READING
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