Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2.

@article{Zhang2017TypicalAI,
  title={Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2.},
  author={Tao Zhang and Delu Che and Rui Liu and Shengli Han and Nan Wang and Yingzhuan Zhan and Priyanka Pundir and Jiao Cao and Yanni Lv and Liu Yang and Jue Wang and Meiwen Ding and Xinzhong Dong and Langchong He},
  journal={European journal of immunology},
  year={2017},
  volume={47 11},
  pages={1949-1958}
}
Mast cells are unique immune cells that function as sentinels in host defence reactions, including immediate hypersensitivity responses and allergic responses. The mast cell-specific receptor named MAS-related G protein-coupled receptor X2 (MRGPRX2) triggers mast-cell degranulation, a key process in anaphylactoid reactions. It is widely observed that antimicrobials can induce pseudo-allergic reactions (i.e. IgE-independent mechanism) with symptoms ranging from skin inflammation to life… CONTINUE READING