Typical Laws of Heredity

  title={Typical Laws of Heredity},
  • Philosophy
  • Nature
WE are far too apt to regard common events as matters of course, and to accept many things as obvious truths which are not obvious truths at all, but present problems of much interest. The problem to which I am about to direct attention is one of these. 

Pictorial Statistics

This essay discusses Francis Galton’s method of inductive inference where the data are photographs of human faces. His aim of induction was to determine the typical characteristics of the natural

Heritability: What's the point? What is it not for? A human genetics perspective

Contrarily to the field of animal and plant genetics for which the polygenic model and the concept of heritability revolutionized selection methods, it is explained why it does not provide answer in human genetics.

The “New Synthesis”

  • N. Barton
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2022
Although quantitative geneticists have long known that adaptive variation is highly polygenic, and that this is essential for efficient selection, this is only now becoming appreciated by molecular biologists—and they still do not have a good framework for understanding polygenic variation or diffuse function.

Explanatory schema and the process of model building

This paper develops an alternative methodology by analyzing historically important cases of idealized statistical modeling that use a three-step explanatory schema involving idealization, mathematical operation, and explanatory interpretation.

On The Calibration of Probability Judgments: Some Critical Comments and Alternative Perspectives

Calibration of probability judgments has attracted in recent years an increasing number of researchers as re ected by an expanding number of articles in the literature on judgment and decision

Evolutionary dynamics of complex traits in sexual populations in a heterogeneous environment: how normal?

  • L. Dekens
  • Mathematics
    Journal of Mathematical Biology
  • 2022
When studying the dynamics of trait distribution of populations in a heterogeneous environment, classical models from quantitative genetics choose to look at its system of moments, specifically the

Families or Unrelated: The Evolving Debate in Genetic Association Studies

This editorial addresses the debate over the relative merits of family- and population-based genetic association studies and details the arguments for the two aforementioned paradigms in recent and current applications.

Was there ever a Ruling Class? Rare Surnames and Long Run Social Mobility in England, 1858-2011

Using rare English surnames we follow the socio-economic status of a group of rich and poor families in 1858-87 over 5 generations. We measure social status both through wealth at death, and through

Investigating shared genetic and environmental aetiology between psychiatric disorders and rheumatoid arthritis

The first dedicated PRS software, PRSice (‘precise’), is presented, for calculating, applying, evaluating and plotting the results of PRS, and illustrated the importance of identifying the best-fit PRS and estimate a P-value significance threshold for high-resolution PRS studies.