Types of DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E and HERV-K in the neutrophils from systemic lupus erythematosus patients and healthy controls

@article{Sukapan2014TypesOD,
  title={Types of DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E and HERV-K in the neutrophils from systemic lupus erythematosus patients and healthy controls},
  author={Patadon Sukapan and Paramate Promnarate and Yingyos Avihingsanon and Apiwat Mutirangura and Nattiya Hirankarn},
  journal={Journal of Human Genetics},
  year={2014},
  volume={59},
  pages={178-188}
}
Changes of the DNA methylation at the interspersed repetitive sequences can occur in various conditions including cancer as well as autoimmune diseases. We previously reported the hypomethylation of LINE-1 and HERV-E in the lymphocytes of systemic lupus erythematosus (SLE) patients. As neutrophils are another important cell type contributing to SLE pathogenesis, in this study, we evaluated the methylation levels and patterns for LINE-1, ALU, HERV-E and HERV-K in the neutrophils from SLE… CONTINUE READING
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