Type-dependent integration frequency of human papillomavirus genomes in cervical lesions.

@article{Vinokurova2008TypedependentIF,
  title={Type-dependent integration frequency of human papillomavirus genomes in cervical lesions.},
  author={S. V. Vinokurova and Nicolas Wentzensen and Irene Kraus and Ruediger Klaes and Corina Driesch and Peter Melsheimer and Fjodor L Kisseljov and M. D{\"u}rst and Achim Schneider and Magnus von Knebel Doeberitz},
  journal={Cancer research},
  year={2008},
  volume={68 1},
  pages={
          307-13
        }
}
Chromosomal integration of high-risk human papillomavirus (HR-HPV) genomes is believed to represent a significant event in the pathogenesis of cervical cancer associated with progression from preneoplastic lesions to invasive carcinomas. This hypothesis is based on experimental data suggesting that integration-dependent disruption of HR-HPV E2 gene functions is important to achieve neoplastic transformation and on clinical data gathered by analyzing lesions induced by human papillomavirus (HPV… Expand
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  • 2017
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Analysis of integration sites of HPV16 and 18 genomes in 21 anogenital precancerous and cancerous lesions and amplification of papilloma virus oncogene transcripts assay suggests that in the progression of cervical preneoplasia to invasive carcinomas, integration of viral genomes occurs only at single or few chromosomal loci in a given cell clone. Expand
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The data at nucleotide resolution confirm that in HPV18-positive cervical tumors, the region surrounding c-myc is indeed a hot spot of viral integration, and demonstrate that CFSs are preferred sites of integration for HPV18 in cervical tumors. Expand
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