Type beta transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro.

@article{Ishibashi1987TypeBT,
  title={Type beta transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro.},
  author={Teruo Ishibashi and Sommer L Miller and Samuel A. Burstein},
  journal={Blood},
  year={1987},
  volume={69 6},
  pages={
          1737-41
        }
}
To investigate the potential role of platelets in the inhibition of megakaryocytopoiesis, freeze-thawed extracts of human platelets were added to serumless liquid cultures of murine marrow. When acetylcholinesterase (AchE), a marker of megakaryocytic differentiation in mice, was assayed, a significant inhibition of enzymatic activity was noted in cultures containing the equivalent of greater than 5 X 10(6) solubilized platelets per milliliter. Freeze-thawed extracts of granulocytes had… CONTINUE READING

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