Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.

@article{Ignotz1985TypeBT,
  title={Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts.},
  author={Ronald Ignotz and Joan Massagu{\'e}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 24},
  pages={
          8530-4
        }
}
Differentiating mouse 3T3-L1 preadipocytes have been used as a model system to study the ability of type beta transforming growth factor (TGF-beta) to modulate cell development. We find that TGF-beta inhibits potently (ID50 approximately equal to 25 pM) the adipogenic conversion of 3T3-L1 cells. Inhibition is observed only when cells are exposed to TGF-beta before they become committed to differentiation. Even a transient (4 hr) exposure to TGF-beta immediately before the commitment point is… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 91 CITATIONS, ESTIMATED 65% COVERAGE

Camurati–Engelmann Disease

  • Calcified Tissue International
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

TGF-β Family Signaling in Mesenchymal Differentiation.

  • Cold Spring Harbor perspectives in biology
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

1987
2019

CITATION STATISTICS

  • 1 Highly Influenced Citations