Type XVII collagen is a key player in tooth enamel formation.

  title={Type XVII collagen is a key player in tooth enamel formation.},
  author={Takuya Asaka and Masashi Akiyama and Takanori Domon and Wataru Nishie and Ken Natsuga and Yasuyuki Fujita and Riichiro Abe and Yoshimasa Kitagawa and Hiroshi Shimizu},
  journal={The American journal of pathology},
  volume={174 1},
Inherited tooth enamel hypoplasia occurs due to mutations in genes that encode major enamel components. Enamel hypoplasia also has been reported in junctional epidermolysis bullosa, caused by mutations in the genes that encode type XVII collagen (COL17), a component of the epithelial-mesenchymal junction. To elucidate the pathological mechanisms of the enamel hypoplasia that arise from the deficiency of epithelial-mesenchymal junction molecules, such as COL17, we investigated tooth formation in… CONTINUE READING
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