Type XVII collagen coordinates proliferation in the interfollicular epidermis

@inproceedings{Watanabe2017TypeXC,
  title={Type XVII collagen coordinates proliferation in the interfollicular epidermis},
  author={Mika Watanabe and Ken Natsuga and Faith Muchemwa and Yasuaki Kobayashi and Giacomo Donati and Shotaro Suzuki and Yu Fujimura and Tadasuke Tsukiyama and Hideyuki Ujiie and Satoru Shinkuma and Hideki Nakamura and Masamoto Murakami and Michitaka Ozaki and Masaharu Nagayama and Fiona M Watt and Hiroshi Shimizu},
  booktitle={eLife},
  year={2017}
}
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the… CONTINUE READING

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