Type VI collagen expression is upregulated in the early events of chondrocyte differentiation.

@article{Quarto1993TypeVC,
  title={Type VI collagen expression is upregulated in the early events of chondrocyte differentiation.},
  author={Rodolfo Quarto and Beatrice Dozin and Paolo Bonaldo and Ranieri Cancedda and Alfonso Colombatti},
  journal={Development},
  year={1993},
  volume={117 1},
  pages={245-51}
}
Dedifferentiated chondrocytes cultured adherent to the substratum proliferate and synthesize large amounts of type I collagen but when transferred to suspension culture they decrease proliferation, resume the chondrogenic phenotype and the synthesis of type II collagen, and continue their maturation to hypertrophic chondrocyte (Castagnola et al., 1986, J. Cell Biol. 102, 2310-2317). In this report, we describe the developmentally regulated expression of type VI collagen in vitro in… CONTINUE READING

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