Type Transforming Growth Factors Promote Interleukin-3 (IL-3)-Dependent Differentiation of Human Basophils But Inhibit IL-3-Dependent Differentiation of Human Eosinophils


Basophils and eosinophils share a common differentiation pathway. Factors regulating terminal committment toward one cell type, however, have so far not been defined. Interleukin-3 (IL-3) is a potent differentiation factor for both human eosinophils and basophils. In the present study, the effects of various recombinant human (rh) growth regulators on IL… (More)


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