Type-Specific Seroprevalence of Herpes Simplex Virus Type 2 and Associated Risk Factors in Middle-Aged Women From 6 Countries: The IARC Multicentric Study

  title={Type-Specific Seroprevalence of Herpes Simplex Virus Type 2 and Associated Risk Factors in Middle-Aged Women From 6 Countries: The IARC Multicentric Study},
  author={Rolando Herrero and Rhoda Ashley Morrow and Nubia Mu{\~n}oz and Francesc X. Bosch and Sin{\'e} Bayo and Brahim El Khalil El Gueddari and Eduardo C{\'a}ceres and Saibua B. Chichareon and Xavier Castellsagué and Chris J.L.M. Meijer and Peter J. F. Snijders and Jennifer S. Smith},
  journal={Sexually Transmitted Diseases},
Goal: To determine type-specific seroprevalence of herpes simplex viruses (HSV-1 and HSV-2) and HSV-2 risk factors. Study Design: Six-hundred fifty eight middle-aged control women (hospital-based in 4 of 6 countries) from a multicenter cervical cancer case–control study participated from 1985 to 1997. Type-specific serum IgG antibodies against HSV-1 and HSV-2 were detected with Western Blot. Results: HSV-1 seroprevalence was 89% to 100% everywhere except Thailand (51%). HSV-2 seroprevalence… 
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