Type-Specific Seroprevalence of Herpes Simplex Virus Type 2 and Associated Risk Factors in Middle-Aged Women From 6 Countries: The IARC Multicentric Study

  title={Type-Specific Seroprevalence of Herpes Simplex Virus Type 2 and Associated Risk Factors in Middle-Aged Women From 6 Countries: The IARC Multicentric Study},
  author={Rolando Herrero and Rhoda Ashley Morrow and Nubia Mu{\~n}oz and Francesc X. Bosch and Sin{\'e} Bayo and Brahim El Khalil El Gueddari and Eduardo C{\'a}ceres and Saibua B. Chichareon and Xavier Castellsagué and Chris J.L.M. Meijer and Peter J. F. Snijders and Jennifer S. Smith},
  journal={Sexually Transmitted Diseases},
Goal: To determine type-specific seroprevalence of herpes simplex viruses (HSV-1 and HSV-2) and HSV-2 risk factors. Study Design: Six-hundred fifty eight middle-aged control women (hospital-based in 4 of 6 countries) from a multicenter cervical cancer case–control study participated from 1985 to 1997. Type-specific serum IgG antibodies against HSV-1 and HSV-2 were detected with Western Blot. Results: HSV-1 seroprevalence was 89% to 100% everywhere except Thailand (51%). HSV-2 seroprevalence… 
Herpes Simplex Virus Type-2 Seropositivity Among Ever Married Women in South and North Vietnam: A Population-Based Study
HSV- 2 was notably less prevalent in Hanoi than HCMC, where it was associated with traditional HSV-2 risk factors, and prevalence ratios were nearly identical to age-adjusted prevalence ratios for marital status, age at first pregnancy, and HPV DNA positivity.
Prevalence of specific herpes simplex virus-2 antibodies and associated factors in women of a rural town of Colombia.
Seroprevalence, Type-Specific of Herpes Simplex Virus and Associated Risk Factors among Women of Child Bearing Age in Kogi State, Nigeria
The prevalence of the HSV-1 andHSV-2 infections was high among asymptomatic healthy women of childbearing age in Kogi state, Nigeria and efforts should be made to increase the awareness of HSV infection among the child bearing populace.
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Seroprevalence of Herpes Simplex Virus Type 2 (HSV-2) in Pregnant Women and its Relation to Some Blood Cells and IL-2 in Kirkuk, Iraq
The seroprevalence of HSV-2 was relatively high in pregnant women in Kirkuk city and there was significant relation of abortion with gestational time of pregnancy in seropositive pregnant women.
The Epidemiology of Herpes Simplex Virus Type 1 in Asia: Systematic Review, Meta-analyses, and Meta-regressions
HSV-1 is probably playing a significant role as a sexually transmitted infection, explaining one-fifth of genital herpes cases, and there is a need for expanded seroprevalence monitoring and GUD/genital herpes etiological surveillance in Asia.
Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions
Age was the strongest predictor of seroprevalence explaining 44.3% of the variation, and Assay type, sex, population type, year of data collection, sample size, and sampling method were not significantly associated with serop revalence.
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One in five adults is HSV-2 infected, a higher level than other world regions, but seroprevalence is declining, and HSv-2 persists as the aetiological cause of nearly half of GUD cases and almost all of genital herpes cases.


High Prevalence of Antibodies to Herpes Simplex Virus Type 2 Among Middle-Aged Women in Mexico City, Mexico: A Population-Based Study
Background Herpes simplex virus type 2 (HSV-2) is among the most prevalent sexually transmitted diseases worldwide. In Mexico there is a lack of population-based HSV-2 surveys. Goals To determine
Prevalence and Risk Factors for Herpes Simplex Virus Type 2 Infection Among Middle-Age Women in Brazil and the Philippines
The higher HSV-2 seroprevalence in Brazil than in the Philippines may be explained largely by differences in the sexual behavior of women and their husbands.
Seroprevalence and Correlates of Herpes Simplex Virus Type 2 Among Urban Tanzanian Women
Age, sexual debut, number of sex partners, and history of spontaneous abortion were found to be significantly associated with HSV-2, which may be the most common cause of genital ulcers in this population of women.
Herpes Simplex Virus Type 2 Infection Among Bar and Hotel Workers in Northern Tanzania: Prevalence and Risk Factors
Control of HSV-2 might be an important strategy for HIV-1 infection prevention in this population of bar and hotel workers in Moshi, Tanzania.
Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review.
Information on age- and sex-specific prevalence of herpes simplex virus (HSV) types 2 and 1 infections is essential to optimize genital herpes control strategies, which increase in importance because
Performance of focus ELISA tests for herpes simplex virus type 1 (HSV-1) and HSV-2 antibodies among women in ten diverse geographical locations.
The sensitivity and specificity of the Focus-HSV-1 and Focus- HSV-2 tests varied by site, and performance data generated in one area may not be applicable to other populations.
Risk Factors for Infection With Herpes Simplex Virus Type 2:: Role of Smoking, Douching, Uncircumcised Males, and Vaginal Flora
Black race, older age, cigarette smoking, douching, a greater number of lifetime sex partners, a history of intercourse with an uncircumcised partner, the presence of vaginal group B Streptococcus, and abnormal vaginal flora were among the independent predictors of HSV-2 infection.
Seroprevalence and Incidence of Sexually Transmitted Diseases in a Rural Ugandan Population
The results of this exploratory study indicate that all STDs included are common in this rural population and the high HSV-2 prevalence rate among adolescents suggests that HSV -2 may be an important risk factor for HIV-1 infection.
Herpes simplex virus type 2 transmission: risk factors and virus shedding.
  • A. Wald
  • Medicine
    Herpes : the journal of the IHMF
  • 2004
Key factors associated with HSV-2 seropositivity include female gender, race (black), history of sexually transmitted infections, increasing numbers of sexual partners, sexual contact with commercial sex workers and low socio-economic status or level of education.
Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer.
HSV-2 infection may act in conjunction with HPV infection to increase the risk of invasive cervical carcinoma and be associated with markers of sexual behavior, but not with cervical HPV DNA positivity.