Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis.

@article{Bairstow2006TypeIP,
  title={Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis.},
  author={Shawn F. Bairstow and Kun Ling and Xiaojing Su and Ari J Firestone and Chateen Carbonara and Richard A. Anderson},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={20632-42}
}
Clathrin-coated vesicles mediate sorting and intracellular transport of membrane-bound proteins. The formation of these coats is initiated by the assembly of adaptor proteins (AP), which specifically bind to membrane cargo proteins via recognition of endocytic sorting motifs. The lipid signaling molecule phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) is critical for this process, as it serves as both a targeting and regulatory factor. PI(4,5)P(2) is synthesized by type I… CONTINUE READING
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