Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions.

@article{Craig2006TypeIP,
  title={Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions.},
  author={Lisa Craig and Niels Volkmann and Andrew S. Arvai and Michael E. Pique and Mark Yeager and Edward H. Egelman and John A. Tainer},
  journal={Molecular cell},
  year={2006},
  volume={23 5},
  pages={651-62}
}
Type IV pili (T4P) are long, thin, flexible filaments on bacteria that undergo assembly-disassembly from inner membrane pilin subunits and exhibit astonishing multifunctionality. Neisseria gonorrhoeae (gonococcal or GC) T4P are prototypic virulence factors and immune targets for increasingly antibiotic-resistant human pathogens, yet detailed structures are unavailable for any T4P. Here, we determined a detailed experimental GC-T4P structure by quantitative fitting of a 2.3 A full-length pilin… CONTINUE READING
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