Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa.

@article{Persat2015TypeIP,
  title={Type IV pili mechanochemically regulate virulence factors in Pseudomonas aeruginosa.},
  author={Alexandre Persat and Yuki F. Incl{\'a}n and Joanne N. Engel and Howard A Stone and Zemer Gitai},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 24},
  pages={7563-8}
}
Bacteria have evolved a wide range of sensing systems to appropriately respond to environmental signals. Here we demonstrate that the opportunistic pathogen Pseudomonas aeruginosa detects contact with surfaces on short timescales using the mechanical activity of its type IV pili, a major surface adhesin. This signal transduction mechanism requires attachment of type IV pili to a solid surface, followed by pilus retraction and signal transduction through the Chp chemosensory system, a chemotaxis… CONTINUE READING

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