Type IV collagenases in invasive tumors

@article{Tryggvason1993TypeIC,
  title={Type IV collagenases in invasive tumors},
  author={Ph.D. Karl Tryggvason and Matti H{\"o}yhty{\"a} and Charles Pyke},
  journal={Breast Cancer Research and Treatment},
  year={1993},
  volume={24},
  pages={209-218}
}
The matrix metalloproteinases appear to be elevated in tumors with metastatic potential, and may well be involved in penetration of the basement membrane and degradation of extracellular proteins including type IV collagen. An imbalance between the 72 kDa and 92 kDa type IV collagenases and the associated tissue inhibitors of these metalloproteinases (TIMPs) may therefore have a role in the invasive phenotype. Cultured tumor cells with invasive potential secrete both type IV collagenases… CONTINUE READING

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Molecular cloning of routine 70 - kDa type IV collagenase and its expression during mouse development

  • P Reponen, C Sahlberg, P Huhtala, T Hurskainen, ThesleffI, K Tryggvason
  • J Biol Chem
  • 1992

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