Type IV collagen and laminin regulate glomerular mesangial cell susceptibility to apoptosis via beta(1) integrin-mediated survival signals.

@article{Mooney1999TypeIC,
  title={Type IV collagen and laminin regulate glomerular mesangial cell susceptibility to apoptosis via beta(1) integrin-mediated survival signals.},
  author={Andrew Mooney and Kathyjo A. Jackson and Roger Bacon and Charles H Streuli and Gwynneth M. Edwards and James A. Bassuk and John Savill},
  journal={The American journal of pathology},
  year={1999},
  volume={155 2},
  pages={
          599-606
        }
}
Postinflammatory scarring is characterized by changes in extracellular matrix (ECM) composition and progressive loss of normal resident cells. In glomerular inflammation there is now evidence that unscheduled apoptosis (programmed cell death) of mesangial and other resident cells may mediate progression to irreversible glomerulosclerosis. In the current study we examined the hypothesis that ECM components may differ in their capacity to support mesangial cell survival by suppression of… CONTINUE READING

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