Type III neuregulin‐1 promotes oligodendrocyte myelination
@article{Taveggia2008TypeIN, title={Type III neuregulin‐1 promotes oligodendrocyte myelination}, author={C. Taveggia and Pratik Thaker and Ashley Petrylak and G. Caporaso and A. Toews and D. Falls and S. Einheber and J. Salzer}, journal={Glia}, year={2008}, volume={56} }
The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of neuregulin‐1 (NRG1), a neuronal signal essential for Schwann cell differentiation and myelination. In contrast to Schwann cells, primary oligodendrocytes differentiate normally when cocultured with dorsal root ganglia (DRG) neurons deficient in type… Expand
Topics from this paper
179 Citations
Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.
- Biology, Medicine
- Human molecular genetics
- 2019
- 13
- PDF
Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy
- Biology, Chemistry
- 2018
- PDF
Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System
- Biology, Medicine
- Neuron
- 2008
- 316
- Highly Influenced
Ablation of neuronal ADAM17 impairs oligodendrocyte differentiation and myelination
- Biology, Medicine
- Glia
- 2019
Differential localization of neuregulin-1 type III in the central and peripheral nervous system
- Biology, Medicine
- Brain Research
- 2011
- 12
The complex world of oligodendroglial differentiation inhibitors
- Biology, Medicine
- Annals of neurology
- 2011
- 114
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system
- Biology, Medicine
- Nature Neuroscience
- 2009
- 43
- PDF
Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness
- Biology, Medicine
- The Journal of Neuroscience
- 2012
- 109
- Highly Influenced
- PDF
References
SHOWING 1-10 OF 79 REFERENCES
WAVE1 Is Required for Oligodendrocyte Morphogenesis and Normal CNS Myelination
- Biology, Medicine
- The Journal of Neuroscience
- 2006
- 94
- PDF
NGF Regulates the Expression of Axonal LINGO-1 to Inhibit Oligodendrocyte Differentiation and Myelination
- Biology, Medicine
- The Journal of Neuroscience
- 2007
- 154
- PDF
Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture
- Biology, Medicine
- The Journal of cell biology
- 1980
- 430
- PDF
Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2000
- 283
- PDF
The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes
- Biology, Medicine
- The Journal of cell biology
- 2001
- 98
- Highly Influential
- PDF
Contrasting effects of mitogenic growth factors on myelination in neuron–oligodendrocyte co‐cultures
- Biology, Medicine
- Glia
- 2007
- 81
Schwann cell invasion of the central nervous system of the myelin mutants
- Biology, Medicine
- Journal of anatomy
- 1997
- 84