Type III neuregulin‐1 promotes oligodendrocyte myelination

@article{Taveggia2008TypeIN,
  title={Type III neuregulin‐1 promotes oligodendrocyte myelination},
  author={Carla Taveggia and Pratik Thaker and Ashley Petrylak and Gregg L. Caporaso and Arrel D. Toews and Douglas L. Falls and Steven Einheber and James L. Salzer},
  journal={Glia},
  year={2008},
  volume={56}
}
The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of neuregulin‐1 (NRG1), a neuronal signal essential for Schwann cell differentiation and myelination. In contrast to Schwann cells, primary oligodendrocytes differentiate normally when cocultured with dorsal root ganglia (DRG) neurons deficient in type… 
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190 Citations
Highly Influential Citations
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190 Citations

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.
TLDR
It is demonstrated that the modulation of axon-to-glial NRG1 type III signaling has beneficial effects and improves myelination defects during development in a model of CHN.
Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy
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It is demonstrated that the modulation of axon-to-glial neuregulin 1 type III signaling has beneficial effects and restores myelination defects during development in a model of CHN.
Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System
Ablation of neuronal ADAM17 impairs oligodendrocyte differentiation and myelination
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It is reported that the neuronal α‐secretase ADAM17 controls oligodendrocyte differentiation and myelin formation in the central nervous system and that secretases are important post‐translational regulators of myelination although the mechanisms controlling CNS and peripheral nervous system (PNS)Myelination are distinct.
Differential localization of neuregulin-1 type III in the central and peripheral nervous system
The complex world of oligodendroglial differentiation inhibitors
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An overview of recently identified negative regulators of oligodendroglial differentiation and their potential relevance for CNS repair in MS is presented.
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system
TLDR
It is proposed that NRDc regulates axonal maturation and myelination in the CNS and PNS, in part, through the modulation of NRG1 shedding.
Axon-glia interactions during central nervous system myelination
TLDR
It is proposed that interactions between axons and the exploratory processes of oligodendrocyte precursor cells (OPCs) lead to myelination and may be similar to those between dendrites and axons that prefigure and lead to synapse formation.
The role of beta1 integrin in myelination and remyelination
TLDR
The first to demonstrate in vivo that pi integrin is important in myelination and remyelination is demonstrated and it is shown that the mitogen-activated protein kinase (MAPK) pathway appears to be important in pi Integrin signaling during myelinations and remYelination.
Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness
TLDR
A previously unrecognized function of FGF receptor signaling in oligodendrocytes that contributes to the regulation of myelin sheath thickness and that uncouples the initiation of ensheathment from the later phase of continued myelin growth is revealed.
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References

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