Type III neuregulin‐1 promotes oligodendrocyte myelination

@article{Taveggia2008TypeIN,
  title={Type III neuregulin‐1 promotes oligodendrocyte myelination},
  author={C. Taveggia and Pratik Thaker and Ashley Petrylak and G. Caporaso and A. Toews and D. Falls and S. Einheber and J. Salzer},
  journal={Glia},
  year={2008},
  volume={56}
}
The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of neuregulin‐1 (NRG1), a neuronal signal essential for Schwann cell differentiation and myelination. In contrast to Schwann cells, primary oligodendrocytes differentiate normally when cocultured with dorsal root ganglia (DRG) neurons deficient in type… Expand
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