Type III neuregulin‐1 promotes oligodendrocyte myelination

@article{Taveggia2008TypeIN,
  title={Type III neuregulin‐1 promotes oligodendrocyte myelination},
  author={Carla Taveggia and Pratik Thaker and Ashley Petrylak and Gregg L. Caporaso and Arrel D. Toews and Douglas L. Falls and Steven Einheber and James L. Salzer},
  journal={Glia},
  year={2008},
  volume={56}
}
The axonal signals that regulate oligodendrocyte myelination during development of the central nervous system (CNS) have not been established. In this study, we have examined the regulation of oligodendrocyte myelination by the type III isoform of neuregulin‐1 (NRG1), a neuronal signal essential for Schwann cell differentiation and myelination. In contrast to Schwann cells, primary oligodendrocytes differentiate normally when cocultured with dorsal root ganglia (DRG) neurons deficient in type… 
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The first to demonstrate in vivo that pi integrin is important in myelination and remyelination is demonstrated and it is shown that the mitogen-activated protein kinase (MAPK) pathway appears to be important in pi Integrin signaling during myelinations and remYelination.
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A previously unrecognized function of FGF receptor signaling in oligodendrocytes that contributes to the regulation of myelin sheath thickness and that uncouples the initiation of ensheathment from the later phase of continued myelin growth is revealed.
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