Type III IFNs in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity.

@article{Deng2011TypeII,
  title={Type III IFNs in pteropid bats: differential expression patterns provide evidence for distinct roles in antiviral immunity.},
  author={Kejian Deng and Christopher J Cowled and Shawn Todd and Gary S Crameri and Elena R. Virtue and Glenn A Marsh and Reuben Klein and Zheng-Li Shi and Linfa Wang and Michelle L. Baker},
  journal={Journal of immunology},
  year={2011},
  volume={186 5},
  pages={3138-47}
}
Bats are known to harbor a number of emerging and re-emerging zoonotic viruses, many of which are highly pathogenic in other mammals but result in no clinical symptoms in bats. The ability of bats to coexist with viruses may be the result of rapid control of viral replication early in the immune response. IFNs provide the first line of defense against viral infection in vertebrates. Type III IFNs (IFN-λs) are a recently identified IFN family that share similar antiviral activities with type I… CONTINUE READING

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