Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.

@article{Yin2012TypeII,
  title={Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.},
  author={Zhiwei Yin and Jihong Dai and Jing Deng and Faruk G Sheikh and Mahwish Natalia and Tiffany P. Shih and Anita Lewis-Antes and Sheela B. Amrute and Ursula Garrigues and Sean Doyle and Raymond P Donnelly and Sergei V. Kotenko and Patricia Fitzgerald-Bocarsly},
  journal={Journal of immunology},
  year={2012},
  volume={189 6},
  pages={2735-45}
}
Plasmacytoid dendritic cells (pDC) are rare cells found in peripheral blood and lymphoid tissues. pDC are considered to be "professional" type I IFN-producing cells and produce 10- to 100-fold more IFN-α than other cell types in response to enveloped viruses or synthetic TLR7 and TLR9 agonists. In this study, purified pDC were found to express high levels of IFN-λ receptor mRNA, as well as cell-surface IFN-λ receptor. We have developed intracellular flow cytometry assays using Abs to IFN-λ1/3… CONTINUE READING