Type II transmembrane serine proteases in cancer and viral infections.

@article{Choi2009TypeIT,
  title={Type II transmembrane serine proteases in cancer and viral infections.},
  author={So-young Choi and Stephanie Bertram and Ilona Glowacka and Young Woo Park and Stefan P{\"o}hlmann},
  journal={Trends in molecular medicine},
  year={2009},
  volume={15 7},
  pages={303-12}
}
Regulated proteolysis of cellular factors is pivotal to tissue development and homeostasis, whereas uncontrolled proteolytic activity is linked to disease. Type II transmembrane serine proteases (TTSPs) are expressed at the cell surface and are thus ideally located to regulate cell-cell and cell-matrix interactions. Increasing evidence demonstrates that aberrant expression of TTSPs is a hallmark of several cancers and recent studies have defined molecular mechanisms underlying TTSP-promoted… CONTINUE READING