Type II topoisomerases--inhibitors, repair mechanisms and mutations.

@article{Heisig2009TypeIT,
  title={Type II topoisomerases--inhibitors, repair mechanisms and mutations.},
  author={Peter Heisig},
  journal={Mutagenesis},
  year={2009},
  volume={24 6},
  pages={465-9}
}
Type II topoisomerases are ubiquitous enzymes that play an essential role in the control of replicative DNA synthesis and share structural and functional homology among different prokaryotic and eukaryotic organisms. Antibacterial fluoroquinolones target prokaryotic topoisomerases at concentrations 100- to 1000-fold lower than mammalian enzymes, the preferred targets of anticancer drugs such as etoposide. The mechanisms of action of both of these types of inhibitors involve the fixation of an… CONTINUE READING

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