Type II skeletal myofibers possess unique properties that potentiate mitochondrial H(2)O(2) generation.

@article{Anderson2006TypeIS,
  title={Type II skeletal myofibers possess unique properties that potentiate mitochondrial H(2)O(2) generation.},
  author={Ethan John Anderson and Peter Darrell Neufer},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={290 3},
  pages={
          C844-51
        }
}
Mitochondrial dysfunction is implicated in a number of skeletal muscle pathologies, most notably aging-induced atrophy and loss of type II myofibers. Although oxygen-derived free radicals are thought to be a primary cause of mitochondrial dysfunction, the underlying factors governing mitochondrial superoxide production in different skeletal myofiber types is unknown. Using a novel in situ approach to measure H(2)O(2) production (indicator of superoxide formation) in permeabilized rat skeletal… CONTINUE READING

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