Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.

  title={Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.},
  author={Byung Hak Ha and Matthew J. Davis and Catherine C Chen and Hua Jane Lou and Jia Gao and Rong Zhang and Michael O. Krauthammer and Ruth Halaban and Joseph Schlessinger and Benjamin E. Turk and Titus J Boggon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 40},
The type II p21-activated kinases (PAKs) are key effectors of RHO-family GTPases involved in cell motility, survival, and proliferation. Using a structure-guided approach, we discovered that type II PAKs are regulated by an N-terminal autoinhibitory pseudosubstrate motif centered on a critical proline residue, and that this regulation occurs independently of activation loop phosphorylation. We determined six X-ray crystal structures of either full-length PAK4 or its catalytic domain, that… CONTINUE READING


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