Type II ligands as chemical auxiliaries to favor enzymatic transformations by P450 2E1.

@article{Mnard2012TypeIL,
  title={Type II ligands as chemical auxiliaries to favor enzymatic transformations by P450 2E1.},
  author={Am{\'e}lie M{\'e}nard and Camilo Fabra and Yue Huang and Karine Auclair},
  journal={Chembiochem : a European journal of chemical biology},
  year={2012},
  volume={13 17},
  pages={2527-36}
}
The remarkable ability of P450 enzymes to oxidize inactivated C-H bonds and the high substrate promiscuity of many P450 isoforms have inspired us and others to investigate their use as biocatalysts. Our lab has pioneered a chemical-auxiliary approach to control the promiscuity of P450 3A4 and provide product predictability. The recent realization that type… CONTINUE READING