Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats.

@article{Pugh1997TypeIG,
  title={Type II glucocorticoid receptor antagonists impair contextual but not auditory-cue fear conditioning in juvenile rats.},
  author={C R Pugh and Monika Fleshner and Jerry W. Rudy},
  journal={Neurobiology of learning and memory},
  year={1997},
  volume={67 1},
  pages={75-9}
}
There is evidence that glucocorticoids may play a role in learning and memory. To further explore this possibility, we examined the effect of the Type II glucocorticoid antagonists on contextual fear conditioning. This conditioning task is dependent on the hippocampal formation, a brain structure known to be rich in glucocorticoid receptors. Rats systemically injected with a Type II antagonist either 1 h prior to conditioning (RU 38486 and RU 40555) or immediately after conditioning displayed… CONTINUE READING