Type II collagen markers in osteoarthritis: what do they indicate?

  title={Type II collagen markers in osteoarthritis: what do they indicate?},
  author={Yves Edgard Henrotin and Shelby Addison and Virginia Kraus and Michelle A Deberg},
  journal={Current opinion in rheumatology},
  volume={19 5},
PURPOSE OF REVIEW We provide a critical review of recent in-vitro, animal and human clinical studies on type II collagen biomarkers. In describing the human studies, we have applied the BIPED (burden of disease, investigative, prognostic, efficacy of intervention, and diagnostic) classification scheme recently proposed by the Osteoarthritis Biomarkers Network (a consortium of five US National Institutes of Health designated sites). Based on this analysis, we propose an update to the… CONTINUE READING

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