Type II collagen gene variants and inherited osteonecrosis of the femoral head.


BACKGROUND Avascular necrosis of the femoral head (ANFH) causes disability that often requires surgical intervention. Most cases of ANFH are sporadic, but we identified three families in which there was autosomal dominant inheritance of the disease and mapped the chromosomal position of the gene to 12q13. METHODS We carried out haplotype analysis in the… (More)


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