Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.

  title={Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes.},
  author={Katarzyna A Dudek and J{\'e}r{\^o}me E Lafont and Aida Martinez-Sanchez and Christopher L Murphy},
  journal={The Journal of biological chemistry},
  volume={285 32},
miRNAs have been shown to be essential for normal cartilage development in the mouse. However, the role of specific miRNAs in cartilage function is unknown. Using rarely available healthy human chondrocytes (obtained from 8 to 50 year old patients), we detected a most highly abundant primary miRNA H19, whose expression was heavily dependent on cartilage master regulator SOX9. Across a range of murine tissues, expression of both H19- and H19-derived miR-675 mirrored that of cartilage-specific… CONTINUE READING


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