Type II collagen deposition in cruciate ligament precedes osteoarthritis in the guinea pig knee.

@article{Young2002TypeIC,
  title={Type II collagen deposition in cruciate ligament precedes osteoarthritis in the guinea pig knee.},
  author={Robert D Young and Anne Vaughan-Thomas and R. J. Wardale and Victor C. Duance},
  journal={Osteoarthritis and cartilage},
  year={2002},
  volume={10 5},
  pages={420-8}
}
OBJECTIVE To examine the collagens in cruciate ligaments of young Dunkin-Hartley guinea pigs, to determine whether a change in specific collagen types is an early feature of the spontaneous osteoarthritis (OA), which consistently develops in the medial compartment of the knee in this strain. DESIGN Collagen types I, II, III, IX, and XI were detected by immunofluorescence microscopy in the anterior and posterior cruciate ligaments of animals at 3, 4-5 and 12 weeks of age. Type II collagen in… CONTINUE READING