Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.

@article{Wu2012TypeIC,
  title={Type II cGMP-dependent protein kinase inhibits EGF-triggered signal transduction of the MAPK/ERK-mediated pathway in gastric cancer cells.},
  author={Yan Wu and Yong-chang Chen and Rui Qu and Ting Lan and Jianrong Sang},
  journal={Oncology reports},
  year={2012},
  volume={27 2},
  pages={553-8}
}
Our previous study found that Type II cGMP-dependent protein kinase (PKG II) is expressed at lower levels in human gastric cancer tissues and cell lines and increasing the expression and activity of PKG II inhibited the proliferation of cancer cell line BGC-823. However, the mechanism through which PKG II inhibits proliferation of gastric cancer cells is… CONTINUE READING