Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses.

@article{Morgado2014TypeIT,
  title={Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses.},
  author={Pedro Morgado and Dattanand M Sudarshana and Lanny Gov and Katherine S. Harker and Tonika Lam and Paolo Casali and Jon P Boyle and Melissa B. Lodoen},
  journal={Infection and immunity},
  year={2014},
  volume={82 10},
  pages={4047-55}
}
Toxoplasma gondii is an obligate intracellular parasite that can cause severe neurological disease in infected humans. CD40 is a receptor on macrophages that plays a critical role in controlling T. gondii infection. We examined the regulation of CD40 on the surface of T. gondii-infected bone marrow-derived macrophages (BMdMs). T. gondii induced CD40 expression both at the transcript level and on the cell surface, and interestingly, the effect was parasite strain specific: CD40 levels were… CONTINUE READING
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