Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences.

@article{Marreiros2016TypeIN,
  title={Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences.},
  author={Bruno C. Marreiros and Filipa V. Sena and Filipe M Sousa and Ana Paula de Lima Batista and M Manuela A Pereira},
  journal={Environmental microbiology},
  year={2016},
  volume={18 12},
  pages={
          4697-4709
        }
}
Type II NADH:quinone oxidoreductases (NDH-2s) are membrane proteins, crucial for the catabolic metabolism, because they contribute to the maintenance of the NADH/NAD+ balance. In several pathogenic bacteria and protists, NDH-2s are the only enzymes performing respiratory NADH:quinone oxidoreductase activity. For this reason and for being considered absent in mammals, NDH-2s were proposed as suitable targets for novel antimicrobial therapies. We selected all sequences of genes encoding NDH-2s… CONTINUE READING
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