Type I signal peptidase from Leishmania is a target of the immune response in human cutaneous and visceral leishmaniasis.

@article{Rafati2004TypeIS,
  title={Type I signal peptidase from Leishmania is a target of the immune response in human cutaneous and visceral leishmaniasis.},
  author={Sima Rafati and Ali Hatef Salmanian and Tahere Taheri and Slavica Masina and C{\'e}dric Schaff and Yasaman Taslimi and Nicolas Fasel},
  journal={Molecular and biochemical parasitology},
  year={2004},
  volume={135 1},
  pages={13-20}
}
The gene encoding type I signal peptidase (Lmjsp) has been cloned from Leishmania major. Lmjsp encodes a protein of 180 amino residues with a predicted molecular mass of 20.5 kDa. Comparison of the protein sequence with those of known type I signal peptidases indicates homology in five conserved domains A-E which are known to be important, or essential, for catalytic activity. Southern blot hybridisation analysis indicates that there is a single copy of the Lmjsp gene. A recombinant SPase… CONTINUE READING
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