Type I signal peptidase and protein secretion in Staphylococcus aureus.

@article{Schallenberger2012TypeIS,
  title={Type I signal peptidase and protein secretion in Staphylococcus aureus.},
  author={Mark A Schallenberger and Sherry M Niessen and Changxia Shao and Bruce J Fowler and Floyd E Romesberg},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 10},
  pages={2677-86}
}
Staphylococcus aureus is an important human pathogen whose virulence relies on the secretion of many different proteins. In general, the secretion of most proteins in S. aureus, as well as other bacteria, is dependent on the type I signal peptidase (SPase)-mediated cleavage of the N-terminal signal peptide that targets a protein to the general secretory pathway. The arylomycins are a class of natural product antibiotics that inhibit SPase, suggesting that they may be useful chemical biology… CONTINUE READING

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Comparative analysis of the roles of HtrA-like surface proteases in two virulent Staphylococcus aureus strains

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