Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.

@article{Crcamo1994TypeIR,
  title={Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.},
  author={Juan M. C{\'a}rcamo and F M Weis and Francesc Ventura and Rotraud Wieser and Jeffrey L. Wrana and Liliana Attisano and Joan Massagu{\'e}},
  journal={Molecular and cellular biology},
  year={1994},
  volume={14 6},
  pages={3810-21}
}
Transforming growth factor beta (TGF-beta) and activin bind to receptor complexes that contain two distantly related transmembrane serine/threonine kinases known as receptor types I and II. The type II receptors determine ligand binding specificity, and each interacts with a distinct repertoire of type I receptors. Here we identify a new type I receptor for activin, ActR-IB, whose kinase domain is nearly identical to that of the recently cloned TGF-beta type I receptor, T beta R-I. ActR-IB has… CONTINUE READING
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