Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

@article{Whitman1988TypeIP,
  title={Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate},
  author={Malcolm Whitman and C. Peter Downes and Marilyn L. Keeler and Tracy L. Keller and Lewis C. Cantley},
  journal={Nature},
  year={1988},
  volume={332},
  pages={644-646}
}
The generation of second messengers from the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdInsP2) by phospho-inositidase C has been implicated in the mediation of cellular responses to a variety of growth factors and oncogene products1–4. The first step in the production of PtdInsP2 from phosphatidyl-inositol (PtdIns) is catalysed by PtdIns kinase. A PtdIns kinase activity has been found to associate specifically with several oncogene products, as well as with the platelet-derived… Expand
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Comparison of the immunoprecipitated PtdIns kinase with the activities identified by ion-exchange chromatography indicates that it is the Type I enzyme which specifically associates with the middle-T/pp60c-src complex and appears to co-precipitate with partially purified platelet derived growth factor (PDGF) receptor. Expand
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The results suggest that the 85 kd phosphoprotein, a putative PI kinase, is a substrate for both the PDGF receptor and MTAg/pp60c-src tyrosine kinase activities. Expand
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