Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.

@article{Tolias1998TypeIP,
  title={Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.},
  author={Kimberly Tolias and Lucia E. Rameh and Hisamitsu Ishihara and Yoshikazu Shibasaki and Jun Chen and Glenn D. Prestwich and Lewis C. Cantley and Christopher L. Carpenter},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 29},
  pages={18040-6}
}
Inositol phospholipids regulate a variety of cellular processes including proliferation, survival, vesicular trafficking, and cytoskeletal organization. Recently, two novel phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PtdIns-3,5-P2) and phosphatidylinositol- 5-phosphate (PtdIns-5-P), have been shown to exist in cells. PtdIns-3,5-P2, which is regulated by osmotic stress, appears to be synthesized by phosphorylation of PtdIns-3-P at the D-5 position. No evidence yet exists for how… CONTINUE READING

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